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organic ‘atlas’ shows dual personality for immune cells that cause class 1 diabetes Immunologists at St. Jude infants’s analysis health center have created a database that identifies gene-regulatory mechanisms in immune cells that facilitate classification 1 diabetes. The findings had been published these days in Nature Immunology. category 1 diabetes is an autoimmune ailment during which the immune device assaults the physique’s personal cells. In category 1 diabetes, immune cells called CD8 T cells kill insulin-producing islet cells in the pancreas. through growing an epigenetic "atlas," the researchers printed that these T cells have a twin biological character. That dual personality permits the T cells to hold the skill to attack insulin-producing cells throughout successive generations of T cells. "an incredible query has been why these T cells stay useful over lengthy durations of time," observed senior writer Ben Youngblood, Ph.D., of the St. Jude department of Immunology. "Our analysis provides critical insights into the steadiness of that response by using organising the vital role of epigenetic programming in human T cell differentiation." legislation via epigenetics The undertaking of cells is ruled with the aid of genetic and epigenetic rules, manage switches that supply guidelines to a telephone. The epigenetic rules mechanisms encompass a technique called methylation in which methyl molecules will also be plugged into DNA molecules at key elements to suppress their genetic recreation. Youngblood and his crew charted the pattern of methylation across the genome of CD8 T cells to be aware the epigenetic programming that governs their construction, or "differentiation," from immature cells called stem-reminiscence T cells. The researchers accumulated statistics on methylation patterns of loads of T cells, ranging from naïve– no longer yet possessing the capacity to assault — to energetic effector cells. From the atlas, investigators discovered that the diabetes-causing T cells possessed a dual personality of both naïve and effector-associated epigenetic courses, revealing for the primary time that the cells have been epigenetic hybrids, possessing both classes. The researchers also performed the equal evaluation on mouse CD8 T cells, revealing they additionally confirmed such a twin personality. understanding a twin personality A key to knowing each the human and mouse atlas turned into a multipotency index developed through co-authors Yiping Fan, Ph.D., of the St. Jude core for applied Bioinformatics, and Caitlin Zebley, M.D., a scientific fellow in the department of Immunology. through cutting-area, desktop-learning tactics, Fan and Zebley interrogated this records to bear in mind the differentiation status of the autoreactive T cells. using this novel index, they have been in a position demonstrate that methylation sites across the T cells’ genome will also be used to foretell a T mobilephone’s differentiation. The autoreactive CD8 T cells scored high on the index, revealing their renovation of the less-differentiated hybrid state. The atlas and the multipotency index present crucial new equipment for constructing cures and diagnosis of class 1 diabetes. "we have an epigenetic signature for these cells that we will use to explore treatments for classification 1 diabetes that set off immunological tolerance of these T cells to keep away from their attack on islet cells," Youngblood observed. The index may well be used as the foundation for a diagnostic tool to foretell which patients would respond to remedies that motivate that tolerance. To advance this work, Youngblood and his colleagues are participating with the Immune Tolerance network to verify data from past scientific trials to look whether the index might predict which sufferers would reply to such treatment plans and which would now not. The ITN, funded with the aid of the countrywide Institute of hypersensitive reaction and Infectious ailments, is a collaboration of researchers geared toward establishing immune tolerance treatment options. The insights from the epigenetic atlas can also be utilized to melanoma immunotherapies, in which T cells are engineered to recognize and selectively assault tumor cells. using the multipotency index, researchers could measure how positive such engineered T cells would be in attacking melanoma cells. The atlas can even be used to take note the character of T phone exercise in chronic viral infections. ### Co-first authors on the paper are Hossam Abdelsamed, formerly of St. Jude and now of the college of Pittsburgh faculty of medication; Caitlin Zebley of St. Jude; and Hai Nguyen of the Benaroya analysis Institute. different authors encompass Hazem Ghoneim, Jeremy Crawford, Ashley Castellaw, Maureen McGargill, Shanta Alli, Shannon Boi and Hongjian Jin all of St. Jude; Eddie James, Gerald Nepom and Cate Speake of the Benaroya research Institute; Rachel Rutishauser and Steven Deeks of the institution of California, San Francisco; Francesca Alfei and Dietmar Zehn of the Technical university of Munich; Susan Pereira Ribeiro and Rafick-Pierre Sekaly of Case Western Reserve tuition; Elisavet Serti of the Immune Tolerance community; Laurence Turka of Massachusetts regular health center and Harvard medical faculty and Michael Busch and Mars Stone of the Vitalant analysis Institute. This research turned into supported by using the countrywide Institutes of fitness (1R01AI114442), the Immune Tolerance community (UM1AI109565), the Assisi groundwork and ALSAC, the fundraising and attention firm of St. Jude. St. Jude babies’s analysis health facility
St. Jude babies’s analysis clinic is leading the manner the area is familiar with, treats and cures childhood cancer and other lifestyles-threatening ailments. it is the simplest countrywide cancer Institute-precise complete melanoma core devoted solely to infants. treatments developed at St. Jude have helped push the ordinary childhood cancer survival price from 20 % to 80 % due to the fact that the sanatorium opened greater than 50 years in the past. St. Jude freely shares the breakthroughs it makes, and every child saved at St. Jude skill docs and scientists worldwide can use that talents to store heaps greater babies. households on no account acquire a bill from St. Jude for remedy, commute, housing and meals — as a result of all a family should fret about is assisting their baby are living. To gain knowledge of more, visit stjude.org or observe St. Jude on social media at @stjuderesearch.
Disclaimer: AAAS and EurekAlert! are not liable for the accuracy of news releases posted to EurekAlert! by contributing associations or for the use of any advice in the course of the EurekAlert gadget. update on the newest sports NBA-time table Greek Freak, Bucks roll past Pistons UNDATED (AP) — The NBA’s precise team and the reigning MVP confirmed no rust following the All-famous person destroy. Giannis Antetokounmpo (YAH’-nihs an-teh-toh-KOON’-poh) had 33 facets and sixteen rebounds because the Bucks mauled the Detroit Pistons, 126-106. Antetokounmpo changed into 13 of 18 from the field and performed simply below 32 minutes with the video game smartly in hand by intermission. The Bucks led 70-forty one at halftime and by way of as many as 34 in the 2d half of their fifteenth win in 17 video games. Former Piston Khris Middleton introduced 28 elements and Eric Bledsoe chipped in 18 as Milwaukee superior to a league-most effective 47-8. checking out Thursday’s different completed NBA motion: — James Harden’s 29 points and 10 assists were among the Rockets’ highlights in a one hundred thirty five-one zero five dismantling of the soldiers. P.J. Tucker become 5-for-5 from three-point range as Houston set a team-list with 25 buckets from beyond the arc. Russell Westbrook had 21 points and 10 assists before being ejected. — Trae young poured in a career-high 50 features and the Hawks closed on a 10-0 run to beat the heat, 129-124. young made 18 of 19 free throws and 8 of 15 three-tips that could support Atlanta overcome Bam Adebayo’s (ad-ah-BAY’-ohz) 28 facets and season-excessive 19 rebounds for Miami. — The 76ers are an NBA-most suitable 26-2 at home after Joel Embiid (joh-EHL’ ehm-BEED’) provided 39 elements and sixteen rebounds in a 112-104 beyond regular time win towards the Nets. Alec Burks brought 19 features, including a pair of layups in additional time that gave Philadelphia the lead for respectable. — The Kings were 129-one hundred twenty five winners over the Grizzlies as Harrison Barnes scored a season-excessive 32 features and matched his career excessive with seven 3-pointers. De’Aaron Fox brought 26 and friend Hield (heeld) chipped in 20, together with 4 free throws within the last seconds. — Malik Monk dropped in 25 points and Miles Bridges contributed 22 within the Hornets’ third straight win, 103-93 at Chicago. Charlotte let a 21-point lead within the third quarter shrink to two earlier than striking on. NBA-news Irving executed for season UNDATED (AP) — Brooklyn Nets look after Kyrie Irving will have arthroscopic surgery on his right shoulder and miss the relaxation of the season. The Nets made the announcement Thursday earlier than taking part in the Philadelphia 76ers of their first video game after the All-celebrity damage. Nets teach Kenny Atkinson mentioned this week that Irving was nevertheless having main issue with the shoulder that sidelined him for 26 video games prior this season. Irving noted pain within the shoulder at first worsened after a video game on Nov. four. He changed into constrained to just 20 video games after signing with the Nets in July. additionally, in the NBA: — Warriors safeguard Klay Thompson will not play this season, notwithstanding it has no longer been ruled out that he could nevertheless compete in the Olympics this summer season. It changed into expected that Thompson would omit the whole season as he recovers from a torn knee ligament. — Timberwolves ahead Jake Layman has been cleared to come to practice, but superstar center Karl-Anthony cities is still sidelined. cities is awaiting clearance for a sprained left wrist. Layman already has missed 39 video games and may pass over as a minimum four greater with a sprained left toe suffered Nov. 18 at Utah. The 6-foot-eight Layman was averaging a profession-greatest 10.5 features over the first 14 video games in his first season with the Wolves. — Dwyane Wade is ready to get the maximum honor the Miami heat can bestow on a former player. Wade will develop into the fifth warmth player to get his quantity retired through the group, becoming a member of Alonzo Mourning, Tim Hardaway, Shaquille O’Neal and Chris Bosh. a 3-day party of Wade’s time in Miami starts on Friday, a weekend highlighted via his No. three formally going to the rafters on Saturday night when the warmth play host to the Cleveland Cavaliers. NFL-news NFL homeowners approve negotiated phrases for brand new labor settlement new york (AP) — NFL house owners have voted to settle for the negotiated phrases for a brand new collective bargaining contract, placing the onus on avid gamers who plan to hold a conference call Friday. group representatives had been summoned to ny to talk about the notion with the league desirous to reach a collective bargaining settlement with the avid gamers within the following few weeks. The current deal runs out in March 2021. among the gadgets in that notion are a 17-online game schedule, a discount of the preseason and a rise to the latest 27% share of revenues for the players. A 2nd bye week to go along with a seventeenth video game is also being regarded, although very nearly not at all for the 2020 season. The enlargement of the playoffs effectively may turn up this year, however. In different NFL information: — Browns seasoned Bowl large receiver Jarvis Landry has passed through hip surgery after at the start opting not to have the operation. Landry turned into by way of his hip all remaining season, but nevertheless accomplished with a group-leading eighty three catches for 1,1174 yards and 6 touchdowns. — The Bears have signed tight end Demetrius Harris to a one-12 months contract. The 6-foot-7 Harris has seventy two receptions for 754 and 9 touchdowns over six seasons with the Chiefs and Browns. He become launched by way of Cleveland this week. — Vikings protecting end Everson Griffen will become a free agent for the primary time in his 11-year profession. Griffen has chosen to undertaking his option to void the last three years on his contract. The circulate will clear greater than $13 million off the books for 2020 for the salary cap-strapped Vikings. — An attorney for new Orleans’ Roman Catholic archdiocese is strongly defending the Saints’ public-members of the family assist in coping with the clergy sex abuse crisis. He says the felony effort to united states of america emails between them is aimed at making an attempt to shame these “who had the audacity” to returned the church. Thursday’s hearing comes amid claims the Saints joined the church in a sample of concealing sexual abuse, an allegation the group denies. — Dan Radakovich, who starred as a linebacker at Penn State within the 1950s before winning two tremendous Bowls as an assistant with the Pittsburgh Steelers in the 1970s, has died. Radakovich changed into eighty four. T25 men’S BASKETBALL-time table Gonzaga continues successful streak UNDATED (AP) — second-ranked Gonzaga earned its nineteenth straight victory and clinched at the least a share of an eighth consecutive West Coast conference general-season title. Killian Tillie scored 22 points and grabbed 9 rebounds as the Bulldogs whipped San Francisco, 71-fifty four. Filip Petrusev delivered 16 points and Ryan Woolridge 12 for the Zags, who squeezed out a four-aspect win over the Dons on Feb. 1. Gonzaga trailed by means of 9 at halftime earlier than outscoring San Francisco, forty nine-23 the relaxation of ways. In other exact-25 finals: — Alonzo Verge Jr. scored 26 features and Rob Edwards added 24 in Arizona State’s sixth straight win, 77-seventy two versus No. 14 Oregon. The ducks blew an eleven-point, 2d-half lead earlier than Edwards drained a 3-pointer to spotlight a 6-0 spurt that put Arizona State ahead for good. — McKinley Wright IV had 15 facets and Tyler Bey delivered 14 with eleven boards as No. 18 Colorado eked out a 70-66 win against Southern California. Shane Gatling chipped in 13 aspects as one among five Buffaloes to ranking in double-figures. — Luka Garza scored 24 facets and 20th-rated Iowa opened on a 27-8 run in an 85-76 win over No. 25 Ohio State. It was his 12th consecutive online game of 20 aspects or more in huge Ten play, the longest streak for an Iowa player in forty nine seasons and probably the most with the aid of any conference player in the closing two decades. — TJ Haws had 28 elements as 23rd-ranked Brigham younger gained its seventh straight online game, defeating Santa Clara eighty five-seventy five. — No. 24 Arizona rolled to an 89-63 rout of Oregon State at the back of Josh eco-friendly’s 18 aspects. Nico Mannion brought sixteen features and 6 assists for the Wildcats. NHL-schedule Caps fall regardless of Ovie’s 699th UNDATED (AP) — Alex Ovechkin (oh-VEHCH’-kihn) ultimately moved closer to the seven-hundred-goal plateau, but the Washington Capitals failed to regain first vicinity in the NHL’s Metropolitan Division. Ovechkin ended a 5-game point drought by netting his 699th profession intention in the Caps’ 4-3 loss to Montreal. The left wing fired up the group by means of scoring in seven minutes in and got here near reaching seven hundred goals on a bang-bang play within the third length. as a substitute, Ovechkin continues his quest to develop into the eighth player in NHL background to get to 700. Ben Chiarot (sheh-RAHT’) scored his 2nd of the game fifty eight seconds into OT to ship the Capitals to their fifth loss in six video games. The Caps grabbed a share of the division lead with the Penguins’ four-0 loss to the Maple Leafs. Jake Muzzin (MUH’-zihn) had a purpose and two assists to returned Frederik Andersen, who made 24 saves in his second shutout of the season and 18th of his career. William Nylander (NEE’-lan-dur), Kasperi Kapanen (kas-PEHR’-ee KAP’-ah-nehn) and Zach Hyman also tallied as Toronto regained third region in the Atlantic Division. somewhere else on NHL ice: — Tampa Bay’s crew-checklist, eleven-video game profitable streak is over after Alec Martinez had a aim and an aid in his Vegas debut to guide a 5-3 victory over the Lightning. Paul Stastny (STAS’-nee), Mark Stone, Ryan Reaves and Max Pacioretty (pash-uh-REH’-tee) also scored as Vegas received its fourth in a row and more desirable to 8-3-2 under coach Pete DeBoer (deh-BOHR’). — St. Louis posted a 1-0 win over the Coyotes as Jordan Binnington needed to cease just 14 photographs for his 2nd consecutive shutout and eighth of his profession. Antti Raanta stopped forty five of the Blues’ season-excessive 46 shots, surrendering best Ryan O’Reilly’s purpose with eight minutes remaining. — The Flyers erased a two-aim deficit earlier than Kevin Hayes scored three:fifty one into beyond regular time to send Philadelphia past Columbus, four-3. The Blue Jackets led 3-1 until Nicolas Aube-Kubel (oh-BAY’ koo-BEHL’) and Claude Giroux (juh-ROO’) tallied 1:26 aside to tie it. — Mark Scheifele (SHY’-flee) snapped a 12-game scoring drought with three energy-play dreams within the Jets’ 5-1 thumping of the Senators. Kyle Connor and Nikolaj Ehlers (NIH’-koh-ly EE’-lurz) also scored for the Jets, who more desirable to 7-2-1 over their closing 10 to movement into the primary wild-card spot within the Western convention. — Gabriel Vilardi had a purpose and an aid in his NHL debut to raise the Kings past the Panthers, 5-four. The 11th general decide upon in the 2017 draft scored the quickest rookie debut purpose in Kings history when he fired a wrist shot past Florida’s Sergei Bobrovsky (boh-BRAHV’-skee) 86 seconds into the game and 10 seconds after hitting the ice. — Mackenzie Blackwood won his fifth straight birth by way of making 36 saves in the Devils’ 2-1 verdict over the Sharks. Defenseman P.k. Subban (SOO’-ban) scored the winner on a power play early in the third period. MLB-information Phils beat Realmuto in arbitration UNDATED (AP) — The Phillies gained their arbitration case towards All-star catcher J.T. Realmuto (ree-al-MOO’-toh), placing teams forward of gamers 7-4 this year and ensuring clubs will finish with a successful checklist. Realmuto will get a elevate from $6.05 million to $10 million as an alternative of his $12.four million request. Realmuto turned into got from the Marlins just earlier than spring practising last yr and earned its 2d straight All-celebrity preference. He finished the season batting .275 with 25 home runs and 83 RBIs. In different MLB news: — Yankees right-hander Luis Severino has been shut down from throwing for the second consecutive spring working towards, this time as a result of correct forearm pain. Severino, who became 26 on Thursday, became sidelined except the remaining weeks of the standard season final year. — Indians pitcher Carlos Carrasco felt pain in his appropriate leg all over a spring working towards exercise and is having assessments. The 32-12 months-historical Carrasco made an inspiring comeback final season after being diagnosed with leukemia. The crew plans to provide an replace on his reputation on Friday. PGA-MEXICO CHAMPIONSHIP McIlroy sizzles in Mexico metropolis MEXICO city (AP) — Rory McIlroy is the chief through one circular of the Mexico Championship, two strokes forward of Bubba Watson and Justin Thomas. McIlroy ripped a four-iron from 275 yards into the thin air at Chapultepec to fifteen ft for eagle on his second hole Thursday, made five extra birdies and opened the Mexico Championship with a 6-under sixty five. this is the handiest World Golf Championship that McIlroy hasn’t received as he tries to join Dustin Johnson as the simplest gamers to win all four of them. Bryson DeChambeau and Billy Horschel are tied with Louis Oosthuizen (WUHST’-hy-zehn) and Corey Connors at minus-3, while Hideki Matsuyama (maht-soo-YAH’-mah), Paul Casey, Patrick Reed and Lee Westwood are amongst six gamers at 2 beneath. NCAA-PITTSBURGH-VIOLATIONS Pitt hoops, football placed on 3 years’ probation by means of NCAA INDIANAPOLIS (AP) — The tuition of Pittsburgh football and guys’s basketball classes were positioned on probation for three years via the NCAA. The corporation says both classes dedicated a sequence of violations between 2015 and 2018. The violations founded around each classes exceeding the variety of dispensed practices throughout that time. Former guys’s basketball train Kevin Stallings became given a 3-yr show-trigger order, which means he have to sit out 30% of his new group’s video games if he is employed during the three-year window of the exhibit-cause order. Stallings is at present out of coaching. Former director of basketball operations Dan Cage also faces a three-year exhibit-trigger order. tuition OF MICHIGAN medical professional-INVESTIGATION tuition of Michigan investigates doctor intercourse abuse claims ANN ARBOR, Mich. (AP) — An Olympic wrestler is accusing a school of Michigan doctor of touching him inappropriately all over scientific tests on the faculty. Andy Hrovat says the medical professional’s attractiveness for such conduct changed into well generic amongst his teammates in the 1990s. Hrovat competed for the U.S. within the 2008 summer time Olympics. He tells The linked Press that the encounters with the late Dr. Robert E. Anderson came about throughout his freshman year in 1998. ‘ Hrovat is the first athlete to make public accusations in opposition t Anderson following complaints this week from other former college students that the medical professional sexually abused them a long time in the past. SOCCER-EQUAL PAY American women seek greater than $66M in damages from US Soccer UNDATED (AP) — gamers on the U.S. women’s country wide crew are looking for more than $66 million in damages as part of their gender discrimination lawsuit towards the U.S. Soccer Federation. The damages were printed in a slew of courtroom papers filed in U.S. District court docket in l. a. ahead of a scheduled may trial. The ladies’s national crew sued the federation closing year alleging unequal pay and treatment than avid gamers on the guys’s countrywide crew. among the many dozens of documents were the separate collective bargaining agreements of the U.S. men’s and girls’s teams. The collective bargaining agreements showed a disparity in bonuses however additionally highlighted the different pay constructions between the two teams. operating-HALF MARATHON-WORLD checklist Yeshaneh units world listing in half marathon in Nike footwear RAS AL KHAIMAH, United Arab Emirates (AP) — Ababel Yeshaneh set a global record within the women’s half marathon in the latest breakthrough with the aid of athletes donning excessive-tech Nike shoes. The Ethiopian runner gained the Ras Al Khaimah Half Marathon in 1 hour, four minutes, 31 seconds. Her time knocked 20 seconds off the previous list set via a further runner in 2017. The guys’s and ladies’s information in each the marathon and half marathon because 2018 have all been damaged through athletes in Nike shoes. World Athletics cleared athletes to hold using Nike Vaporfly-style shoes ultimate month. nevertheless it warned that new shoe technology might threaten the activity’s integrity. Copyright © The linked Press. All rights reserved. This cloth may additionally now not be published, broadcast, rewritten or redistributed. ZDFneo, Programmänderung Mainz, 30. März 2020 30.03.2020 – sixteen:15 ZDFneo Mainz (ots) Woche 14/20 Mittwoch, 01.04. Bitte Programmänderungen und Zeitkorrektur beachten: 0.00 death in Paradise Willkommen im Paradies (vom 30.7.2012) DI Richard Poole Ben Miller Lily Thomson Lenora Crichlow Dwayne Myers Danny John-Jules Camille Bordey Sara Martins Fidel best Gary Carr Commissioner Selwyn Patterson Don Warrington Lawrence Karl Collins James Lavender Rupert Graves DI Charlie Hulme Hugo Speer Marlon Collins Sean Maguire Sarah Lavender Coralie Audret Daphné Laurence Joseph bank supervisor Dominik Bernard und andere Buch: Robert Thorogood Regie: Charlie Palmer Gemeinschaftsproduktion von red Planet photos und Kudos film and tv Großbritannien 2011 0.50 death in Paradise Nur die Sonne conflict Zeuge (vom 30.7.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel ideal Gary Carr Catherine Élisabeth Bourgine Darren Moore Matt Di Angelo Lisa Watson Charlotte Salt Diana Watson Frances Barber Mike Watson Robert Pugh Adam festivals Luke Allen-Gale William Paterson Joseph Margaret Camilla Marie Beeput Buch: Robert Thorogood Regie: Robert Goldby Gemeinschaftsproduktion von red Planet pictures und Kudos movie and tv Großbritannien 2011 1.40 loss of life in Paradise Der Voodoo-Zauber (vom 6.eight.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel highest quality Gary Carr Catherine Élisabeth Bourgine Angelique Morel Mona Hammond Molly Kerr Clare Holman Nicholas Dunham Nicholas Farrell Father Charles Dean Michael Maloney Comm. Selwyn Patterson Don Warrington Buch: Robert Thorogood Regie: Charlie Palmer Gemeinschaftsproduktion von pink Planet photos and Kudos movie and television Großbritannien 2011 2.35 dying in Paradise Beste Freunde (vom 6.8.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel top-quality Gary Carr Catherine Élisabeth Bourgine Lucas Talbot Neil Stuke Megan Talbot Miranda Raison Patrick Knight Derek Riddell Astrid Knight Emma Fielding Buch: Robert Thorogood Regie: Roger Goldby Gemeinschaftsproduktion von pink Planet photographs and Kudos film and tv Großbritannien 2011 three.25 death in Paradise Mord an Bord (vom 13.8.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel top-rated Gary Carr Catherine Élisabeth Bourgine Vincent Carter Colin Salmon Leon Hamilton Jeff Alexander Suzie Park S Sarah smart Samuel King Lee Boardman Buch: Harry Holmes, Robert Thorogood Regie: Alfred Lot Gemeinschaftsproduktion von purple Planet pictures and Kudos film and television Großbritannien 2011 four.20 death in Paradise Tropisches Fieber (vom 13.eight.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel premiere Gary Carr Catherine Élisabeth Bourgine Benjamin Lightfoot Alex Lanipekun Abigail Lightfoot Riann Steele Alex Owen Lisa Faulkner Phil Owen Sean Gallagher Mark Lightfoot O.T. Fagbenle Commissioner Selwyn Patterson Gary Carr DS Angela younger Shirley Henderson Danny Fernandez Kieran O’Brian Buch: Robert Thorogood Regie: Alfred Lot Gemeinschaftsproduktion von pink Planet photos and Kudos movie and tv Großbritannien 2011 5.10 death in Paradise -6.05 Falsche Töne (vom 20.8.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel most excellent Gary Carr Catherine Élisabeth Bourgine Solly Johann Myers Curtis Ray Fearon Eddie Keith Duffy Renward Robbie Gee Michelle Bouchant Rebecca Scroggs Buch: Robert Thorogood Regie: Paul Harrison Gemeinschaftsproduktion von purple Planet pictures and Kudos movie and television Großbritannien 2011 (Die Sendungen "Breakdown", "Countdown Copenhagen II" um 1.25 Uhr und 2.10 Uhr "Atlantis der Nordsee", "Wildes Wetter – auf den Spuren der Klimaforschung" "Stonehenge – Das verborgene Reich" und "Die Kelten" entfallen. "An Tagen wie diesen" wird auf Donnerstag, 02.04.2020 verschoben.) Donnerstag, 02.04. Bitte Programmänderungen beachten: 6.05 demise in Paradise Bellende Hunde (vom 20.eight.2012) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel ideal Gary Carr Catherine Élisabeth Bourgine DCI Chris Ricketts John Thomson Aidan Miles Adrian Dunbar Nadia Selim Randiane Naly Georgie Westcott Fiona Glascott Jon Taylor Danny Webb Buch: Robert Thorogood Regie: Paul Harrison Gemeinschaftsproduktion von purple Planet images and Kudos film and tv Großbritannien 2011 6.55 Terra Xpress In letzter Sekunde (vom 21.7.2012) 7.25 An Tagen wie diesen Der 1. April (vom 29.three.2020) Deutschland 2020 (Die Sendungen "Die Kelten" um 6.40 Uhr und 7.25 Uhr entfallen. Weiterer Ablauf ab 8.10 Uhr wie vorgesehen.) Woche 15/20 Samstag, 04.04. Bitte Programmänderungen beachten: 1.15 dying in Paradise Der blutige Finger (vom 2.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel choicest Gary Carr Catherine Élisabeth Bourgine Nicole Seymour Stephanie Beacham Roger Seymour James Cosmo Louis Nelson David Ajala Buch: Delinda Jacobs Regie: Keith Boak Großbritannien 2012 2.10 dying in Paradise Der Graf von Monte Christo (vom 2.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel most effective Gary Carr Father John Kenneth Granham Sister Anne Gemma Jones Sister Marguerite Rowena King Therese Georgina Campbell Catherine Élisabeth Bourgine Daryl Dexter Patrick Baladi Laura Masters Caroline Langrishe three.00 death in Paradise Der 3-Uhr-Tee (vom 9.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel most effective Gary Carr Catherine Élisabeth Bourgine Valerie Dupree Julie Riley Jayne Smythe Cherie Lunghi Carlton Banks Nathaniel Martello-White Comm. Selwyn Patterson Don Warrington Jeremy Tipping James Fleet Paul Vincent Shaun Parkes Anna Jones Emma Pierson Buch: Dan Sefton Regie: David O’Neill Großbritannien 2012 three.50 demise in Paradise Der Fluch des Piraten (vom 9.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel top-rated Gary Carr Catherine Élisabeth Bourgine Liz Curtis Kelly Adams Dr. Ian Parks Rob Heanley Daniel Morgan Jonathan Cake Chris Winchester Ben Turner Benjamin Sammy Bryan Dick Comm. Selwyn Patterson Don Warrington Joel Maurice Michael Brandon e-book Pip Torrens Buch: Robert Thorogood Regie: Alrick Riley Großbritannien 2012 4.forty dying in Paradise Das letzte Lied (vom sixteen.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel ultimate Gary Carr Catherine Élisabeth Bourgine Eloise Morrison Amanda Mealing Stephen Morrison Jonny Phillips Colin Smith Rob Jarvis Milton Reynards Junior Simpson Aimee Fredericks Jamelia RJ Dylan Edwards grant Dexter Fletcher Comm. Selwyn Patterson Don Warrington Buch: Jack Lothian Regie: Keith Boak Großbritannien 2012 5.35 death in Paradise -6.25 Der Seidenschal (vom 16.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel most beneficial Gary Carr Catherine Élisabeth Bourgine Doug Anderson Neil Pearson June Anderson Kim Thomson Estelle du Bois Michelle Austin Will Teague Ralf Little James Murray Ronnie Stuart Janice Palmer Matilda Ziegler Lily Shaw Hannah Spearritt Buch: Colin Bytheway Regie: Alrick Riley Großbritannien 2012 (Die Sendungen "Das siebte Zeichen" um 1.15 Uhr, "The Killer internal" um 2.50 Uhr, 3.30 Uhr und four.10 Uhr sowie "Deutschland von oben 4: Stadt" entfallen. "Terra Xpress" wurde auf den 02.04.2020 vorgezogen.) Sonntag, 05.04. Bitte Programmänderungen beachten: 6.25 demise in Paradise Das Auge des Hurrikans (vom 23.7.2013) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel most useful Gary Carr Professor King Stephen Boxer Jennifer Cheung Gemma Chan Amber Collins Jo Woodcock Leo Downs Matthew Horne Damon Ryan Ben Batt Judy Hearst Lolita Chakrabati Buch: James Payne Regie: David O’Neill Großbritannien 2012 7.15 demise in Paradise Ein (fast) perfekter Plan (vom 23.7.2017) DI Richard Poole Ben Miller Camille Bordey Sara Martins Dwayne Myers Danny John-Jules Fidel ideal Gary Carr Catherine Élisabeth Bourgine Vicky Woodward Lucy Davis Malcolm Powell Sean Pertwee Jen Powell Julie Graham Duncan wood Lucien Laviscount Comm. Selwyn Patterson Don Warrington Jamie Grainger Jamie Davis Buch: Robert Thorogood Regie: Alrick Riley Großbritannien 2012 (Die Sendungen "Deutschland von oben 4: Land", "Die Magie der Farben" um 6.45 Uhr und 7.30 Uhr entfallen. Weiterer Ablauf ab 8.15 Uhr wie vorgesehen.) Montag, 06.04. Bitte Programmänderungen beachten: 2.05 dying in Paradise Tickende Uhren (vom 26.8.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel top-quality Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine DI Richard Poole Ben Miller Angela Birkett Sophie Thompson Roger Sadler Tim Dutton James Moore Mark Bazeley Sasha Moore Helen Baxendale Commissioner Selwyn Patterson Don Warrington und andere Buch: Robert Thorogood Regie: Cilla Ware Großbritannien 2013 2.fifty five demise in Paradise Tödliche Schokolade (vom 26.8.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel most effective Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Lexi Michelle Ryan Carl Rhys Thomas Susie Hannah Tointon und andere Buch: Daisy Coulam Regie: Cilla Ware Großbritannien 2013 three.50 demise in Paradise Wahrheit und Fälschung (vom 2.9.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel foremost Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Leo Pascal Adrian Scarborough decide Stone Josette Simon Dorothy Foster Sharon Small Carlton Paris Steven Cole und andere Buch: Paul Logue Regie: Dusan Lazarevic Großbritannien 2013 4.forty loss of life in Paradise Mord mit Verspätung (vom 2.9.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel most desirable Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Natasha Thiebert Félicité Du Jeu Adam Frost Raza Jaffrey Paul Bevans Daniel Lapaine Max Leigh Chris Geere Simone Magon Kathryn Drysdale Helen Walker Sophie Colquhoun und andere Buch: Ian Kershaw Regie: Dusan Lazarevic Großbritannien 2013 5.30 dying in Paradise -6.20 Familienbande (vom 9.9.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel gold standard Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Jacob Doran Simon Shepherd Theo Frazier Eriq Ebouaney Charlotte Doran Haydn Gwynne Drew Doran James Musgrave Lena Bell Nina Toussaint-White Marlon Croft Clarke Peters und andere Buch: Robert Thorogood Regie: Robert Quinn Großbritannien 2013 (Die Sendungen "heute-demonstrate" um 2.05 Uhr, "Laura Karasek – Zart am restrict", "Deutschland von oben4" um three.20 Uhr und four.10 Uhr, "Frag den Lesch" und "Die Magie der Farben" um 5.10 Uhr und 5.fifty five Uhr entfallen.) Dienstag, 07.04. Bitte Programmänderungen und Zeitkorrekturen beachten: 6.20 demise in Paradise Der Ruf der Wildnis (vom 9.9.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel most effective Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Captain Jack Paul Barber Dan Parish Ciarán McMenamin Alec Burton Mark Heap Yasmin Blake Hannah John-Kamen und andere Buch: Robert Thorogood Regie: Robert Quinn Großbritannien 2013 7.15 loss of life in Paradise Der Sturm (vom 16.9.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel most suitable Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Joseph Jackson Christopher Obi Alexander Jackson Joseph Marcell Rosie Curloo Pippa Bennett-Warner und andere Buch: Robert Thorogood Regie: Richard Signy Großbritannien 2013 eight.05 loss of life in Paradise Liebeleien (vom sixteen.9.2014) DI Humphrey Goodman Kris Marshall DS Camille Bordey Sara Martins Sergeant Fidel premier Gary Carr Officer Dwayne Myers Danny John-Jules Catherine Élisabeth Bourgine Colin Campbell Rupert Vansittart Emma Redding Kate Fahy Sylvaine Dor Sarah Niles David Witton Philip Jackson Sally Goodman Morven Christie Commissioner Selwyn Patterson Don Warrington und andere Buch: Robert Thorogood Regie: Richard Signy Großbritannien 2013 9.00 Topfgeldjäger Das Duell am Herd mit Steffen Henssler (vom 29.4.2014) Deutschland 2012 9.50 Stadt, Land, Lecker (vom 20.2.2020) Deutschland 2018 10.35 Bares für Rares Die Trödel-reveal mit Horst Lichter (ZDF 6.four.2020) Deutschland 2020 (Die Sendungen "Albrecht Dürer – celebrity", "Marco Polo – Entdecker oder Lügner?" und "Bares für Rares" um 10.35 Uhr entfallen. Weiterer Ablauf ab eleven.30 Uhr wie vorgesehen.) Pressekontakt: ZDF Presse und InformationTelefon: +49-6131-70-12121 normal-content von: ZDFneo, übermittelt durch information aktuell.
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